Hotels in Seneca

Best Seneca Hotels

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14 Best Hotels to Stay in Seneca

Trip.com brings you a curated list of top accommodations in Seneca, complete with reviews, price insights, and amenity highlights, making it easy to find the perfect place to stay.
Most Booked
Lowest Price
Closest to Downtown
Highest Rated
Best Western Seneca-Clemson Hotels in Seneca
Best Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in Seneca
43
Hotels in Seneca
Public parking
24-hour front desk
Wake-up call
"My experience will gyood. The front desk clerk is very kind."
Very Good
102 reviews
8.3/10
1 night
From US$100
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Historic Seneca Bungalow Hotels in Seneca
Historic Seneca Bungalow Hotels in SenecaHistoric Seneca Bungalow Hotels in SenecaHistoric Seneca Bungalow Hotels in SenecaHistoric Seneca Bungalow Hotels in SenecaHistoric Seneca Bungalow Hotels in SenecaHistoric Seneca Bungalow Hotels in Seneca
28
Hotels in Seneca
Wi-Fi in public areas
This location is perfect to relax with boutique shopping and eating on Ram Cat Alley in downtown Seneca only 2 blocks away, zip over to Clemson University (10 minute drive to the stadium) and catch a game, or drop your boat in Lake Keowee or Lake Hartwell and float to your heart's desire. This quaint, historic house has been updated for comfort keeping the original charm in its peaceful location just far enough off the beaten path to be quiet but close enough to reach any number of shops.About pets:No pets allowed.About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 3-17.About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 25.About events:No events allowed.
Outstanding
16 reviews
9.8/10
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Boutique hotel in historic downtown Seneca. Room #5, two King beds. Hotels in Seneca
Boutique hotel in historic downtown Seneca. Room #5, two King beds. Hotels in Seneca
2
Hotels in Seneca
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building underwent an expansive renovation to create a charming, 6 bedroom boutique hotel. Each of our six private rooms are connected with a common area for dining and lounging. Each room features luxury furnishings and bedding, a private bath with a state of the art shower, and 65” Flat Screens, with all your favorite channels. Just steps from your hotel is Ram Cat Alley featuring a variety of locally owned shops, restaurants and nightlife. A short fifteen minute drive will take you to Clemson and the heart of Tiger Town, Clemson University. Head the opposite direction and enjoy the outdoors on Lake Keowee, Lake Jocassee or hiking and viewing one of the twenty-five waterfalls Oconee County has to offer.About pets:No pets allowed.About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 3:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
Outstanding
11 reviews
9.8/10
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Private Room #3 Hotels in Seneca
1
Hotels in Seneca
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building underwent an expansive renovation to create a charming, 6 bedroom boutique hotel. Each of our six private rooms are connected with a common area for dining and lounging. Each room features luxury furnishings and bedding, a private bath with a state of the art shower, and 65” Flat Screens, with all your favorite channels. Just steps from your hotel is Ram Cat Alley featuring a variety of locally owned shops, restaurants and nightlife. A short fifteen minute drive will take you to Clemson and the heart of Tiger Town, Clemson University. Head the opposite direction and enjoy the outdoors on Lake Keowee, Lake Jocassee or hiking and viewing one of the twenty-five waterfalls Oconee County has to offer.About pets:No pets allowed.About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 3:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
Great
5 reviews
9.2/10
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Boutique hotel in historic downtown Seneca. Room #4, King bed. Hotels in Seneca
1
Hotels in Seneca
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building underwent an expansive renovation to create a charming, 6 bedroom boutique hotel. Each of our six private rooms are connected with a common area for dining and lounging. Each room features luxury furnishings and bedding, a private bath with a state of the art shower, and 65” Flat Screens, with all your favorite channels. Just steps from your hotel is Ram Cat Alley featuring a variety of locally owned shops, restaurants and nightlife. A short fifteen minute drive will take you to Clemson and the heart of Tiger Town, Clemson University. Head the opposite direction and enjoy the outdoors on Lake Keowee, Lake Jocassee or hiking and viewing one of the twenty-five waterfalls Oconee County has to offer.About pets:No pets allowed.About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 3:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
Amazing
14 reviews
9.4/10
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Fairfield Inn & Suites Seneca Clemson Univ Area Hotels in Seneca
Fairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in Seneca
84
Hotels in Seneca
Gym
24-hour front desk
Wi-Fi in public areas
"Very clean, the surrounding environment is also very beautiful, there is also breakfast, a very cost-effective hotel"
Great
76 reviews
9.2/10
1 night
From US$129
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Boutique hotel in historic downtown Seneca. Room #6, King Bed. Hotels in Seneca
1
Hotels in Seneca
Welcome to the heart of downtown Seneca, South Carolina. Formerly the Richardson Theatre in the late 50s, our building underwent an expansive renovation to create a charming, 6 bedroom boutique hotel. Each of our six private rooms are connected with a common area for dining and lounging. Each room features luxury furnishings and bedding, a private bath with a state of the art shower, and 65” Flat Screens, with all your favorite channels. Just steps from your loft is Ram Cat Alley featuring a variety of locally owned shops, restaurants and nightlife. A short fifteen-minute drive will take you to Clemson and the heart of Tiger Town, Clemson University. Head in the opposite direction and enjoy the outdoors on Lake Keowee, Lake Jocassee or hiking and viewing one of the twenty-five waterfalls Oconee County has to offer.About pets:No pets allowed.About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 3:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
Amazing
20 reviews
9.4/10
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Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in Seneca
Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in SenecaBeautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in SenecaBeautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in SenecaBeautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in SenecaBeautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in SenecaBeautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Hotels in Seneca
29
Hotels in Seneca
Golf course
Horse riding
Hiking
Our home is situated on a quiet cul-de-sac that shares a point at the south end of Lake Keowee with a panoramic view of Lake Keowee. Our home is just 11 miles from Clemson and is minutes by boat to South Cove boat ramp and Keowee Marina. Also, we are close to town for shopping, restaurants, groceries, pharmacy and the hospital. Our home is family friendly sleeping up to 15 people. We feature very deep water with a very large covered dock that easily holds three boats. Each bedroom has amazing views of Lake Keowee. Four bedrooms with 4 full bathrooms includes a bunk room for kids. The home is located on a gentle sloping lot. Two Master King bedrooms on the main floor with attached bathrooms. These rooms also have an additional single bed in each room. Downstairs has two additional bedrooms with attached two full bathrooms. One room has two single beds and the 4th bedroom has two bunk-beds with double beds below and single beds above. We also have another sleeper sofa and also a set of bunk-beds built into the wall in the main area downstairs. Please check out our flat rate prices for certain weekends and summer weeks.About pets:Pets allowed: dogs less than 50 lbs per pet (limit 2 pets total).Dogs only. Added $100 cleaning!.About checkOut:Check out before 10:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 25.About events:No events allowed.
Outstanding
36 reviews
9.8/10
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Beautiful home near Clemson Hotels in Seneca
Beautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in Seneca
12
Hotels in Seneca
Convenient to anywhere you would like to be in our area. Less than a mile from shops, restaurants, breweries, Jazz on the Alley, and just 13 minutes away from Clemson University. This home is freshly remodeled throughout with new appliances, furniture, and tv’s as well.About pets:No pets allowed.About checkOut:Check out before 10:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 22.About events:No events allowed.
Amazing
5 reviews
9.4/10
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Hampton Inn & Suites Seneca-Clemson Area Hotels in Seneca
Hampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in Seneca
99+
Hotels in Seneca
Public parking
EV charging station
Gym
Welcome to the Hampton Inn & Suites Seneca-Clemson Area, a warm and welcoming hotel just a short distance from Lake Keowee and downtown Seneca, SC. Enjoy easy access to local restaurants, state parks, lakes and leisure amenities including golf. Popular Seneca attractions including the Blue Ridge Mountains, the World of Energy and Clemson University are all close to our relaxed hotel in Seneca, SC. Settle in to a beautifully decorated guest room or suite, where you can stay connected with free WiFi at the ergonomic desk, watch the satellite TV and get a great night's sleep on the clean and fresh Hampton bed. Other great amenities include an in-room microwave and refrigerator and guest laundry facilities are available at this Seneca hotel. Every morning, enjoy Hampton's free hot breakfast buffet, offering everything from light continental favorites to hot items and buy snacks at any time from the 24-hour Suite Shop. Enjoy free tea and coffee in the modern lobby, 24-hours a day and ask our friendly staff for advice on what to see and do during your stay. Stay connected with the free business center or hold a meeting in the 600 sq.ft. conference room. Energize in the free fitness center, swim in the outdoor, saltwater pool or relax under an umbrella on the poolside patio area. Friendly service, clean rooms, comfortable surroundings, every time. If you're not satisfied, we don't expect you to pay. That's our commitment and your guarantee. That's 100% Hampton.
Great
95 reviews
9.2/10
1 night
From US$139
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What Travelers Said About the Best Hotels in Seneca

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Browse these genuine traveler ratings and real guest reviews to find the best Seneca hotels.
7.9/10
Good
TTedRoom was clean and the bed linens smelled fresh. The front office staff and maids were all amiable and happy to be helpful. Breakfast was carb city. Did have self made hot waffles, muffins, cereals, yogurt bananas and coffee n juice. We stayed three nights and would be happy to go back.
Quality Inn Seneca US-123 Hotels in Seneca

Quality Inn Seneca US-123

Hotel near Seneca
Price per night from:US$89
6.9/10
MMandy BriceIt was ok, not bad. Would stay again definitely. Could work on amenities. No conditioner toothpaste. But overall it was a pleasure to have stayed
Days Inn by Wyndham Seneca / Clemson Area Hotels in Seneca

Days Inn by Wyndham Seneca / Clemson Area

Hotel near Seneca
Price per night from:US$85

FAQs About Seneca Hotels

What are some of the best hotels in Seneca?

Whether you're planning a business trip or a vacation, Seneca has many top-rated hotels to choose from. Days Inn by Wyndham Seneca / Clemson Area (price from US$68), Best Western Seneca-Clemson (price from US$92) and Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$129) are among the best choices for your stay.

How to get good deals on hotels in Seneca?

Find the best hotel deals and promotions on Trip.com, available year-round for both first-time and loyal users. Please check the promotions page to see what promotions are available now on Trip.com.

Which hotels in Seneca provide fitness facilities?

Days Inn by Wyndham Seneca / Clemson Area (price from US$68), Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$129) and Hampton Inn & Suites Seneca-Clemson Area (price from US$110) include fitness facilities, so you can maintain your routine while traveling. Stay on track with your fitness goals while on the go!

Which hotels in Seneca have pools?

Days Inn by Wyndham Seneca / Clemson Area (price from US$68), Best Western Seneca-Clemson (price from US$92) and Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$129) are excellent options for hotels with swimming pools. Book your stay to enjoy the pool and make your trip more enjoyable.

What hotels in Seneca offer an especially good breakfast?

What are some good hotel options near Bertha Lee Strickland Cultural Museum in Seneca?

Based on traveler reviews, some of the top-rated hotels near Bertha Lee Strickland Cultural Museum in Seneca include Best Western Seneca-Clemson (price from US$92), Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$129) and Days Inn by Wyndham Seneca / Clemson Area (price from US$68), all known for their excellent service and prime locations.

What are the must-see spots in Seneca?

Seneca is packed with incredible must-see landmarks, like Bertha Lee Strickland Cultural Museum and South Cove County Park.

Seneca Hotels Info

Highest PriceUS$447
Number of Reviews 577
Total Properties14
Average Price(Weekday Night)US$127
Average Price(Weekend Night)US$147